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Sci Rep 16 , 2987 (2026)

The Journal of Biological Chemistry, 287 (6), 41774187

Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2

A systematic review of randomized controlled trials found that NAC improved ovulation and pregnancy rates compared to placebo in women with PCOS, though the authors noted variability in study quality.66 More recent meta-analytic research continues to evaluate NAC across both reproductive and metabolic outcomes, suggesting it may offer measurable benefits for some individuals particularly when ovulatory dysfunction and metabolic stress are present.67 You can explore how NAC is used in PCOS research and see our top-rated options in our complete guide to NAC supplements