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Description
The neuroprotective effects of curcumin are particularly evident in Alzheimers disease, where it addresses multiple pathological features including cholinergic system dysfunction, oxidative damage, and broader nervous system impairment
These did not show therapeutic benefit, some reasons postulated for this include crosstalk between the IGF-1R and other growth factor pathways such as the IR (Robertson et al., 2013

However, melatonin has also been shown to upregulate NMDA receptor subunits 2A and 2B in a dose-dependent manner in the rat hippocampus [80]

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