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68 FGF21 has also been reported to protect against diabetic cardiomyopathy in part through the activation of the AMPK-PON1 signaling 69 and cardiac hypertrophy and fibrosis during hypertension, 70 as well as suppress lipid- or diabetes-stimulated cardiac apoptosis via ERK1/2-p38 MAPK-AMPK pathway
Sodium-dependent vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: roles of collagen and demethylation

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112 It was delivered as a dissolvable powder along with metformin and compared with a placebo formulation containing the same dose of drug
