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In dopaminergic treatment, a subsequent increase in serum BDNF was shown to predict motor outcomes that were observable and registered as improvement on UPDRS scores

Phentermine is an appetite suppressant that works in the brain

Also here is the science behind it

In a prospective case-control study of 14,916 male physicians, those in the highest 5% of homocysteine levels had a 3.1x greater risk of heart attack compared with those in the bottom 90%
