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In addition, IDH1-dependent reductive glutamine metabolism produces NADPH, which decreases mitochondrial ROS during anchorage-independent growth 64

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10.1080/01635581.2012.721156 3 AmagaseH.PeteschB

Figure 2 3.1 Oxidative stress signaling pathway In patients with RA, the presence of superoxide anion radicals in the bloodstream can be converted into hydrogen peroxide due to heightened activity of superoxide dismutase (SOD), but the hydrogen peroxide was not neutralized by catalase (CAT) or glutathione