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So it is advisable to get your vitamin B12 levels tested before you start taking its supplements

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Abbreviations DPPOS: Diabetes Prevention Program Outcomes Study GWAS: Genome-wide association study IF: Intrinsic factor MHRA: Medicines and Healthcare products Regulatory Agency PPI: Proton pump inhibitor QC: Quality control UKB: UK Biobank References Kim J, Ahn CW, Fang S, Lee HS, Park JS (2019) Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes

Current treatment options include approved drugs such as serotonin-norepinephrine reuptake inhibitors, e.g., duloxetine, gabapentinoids such as pregabalin and gabapentin, topical treatment with capsaicin, and several off-label use drugs such as other antidepressants (e.g., tricyclic antidepressants), antiepileptic drugs, and weak and strong opioids