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COVID patients and controls were excluded if they had a lifetime history of psychiatric axis-1 disorders, including major affective disorders such as major depression and bipolar disorder, dysthymia, GAD and panic disorder, schizo-affective disorder, schizophrenia, psycho-organic syndrome, and substance use disorders, except tobacco use disorder (TUD)

In this regard, topical insulin therapy has been effectively used to treat challenging ocular diseases such as persistent epithelial defect, chemical corneal epithelial injury, and refractory corneal ulcers [15,16,17]

[DOI] [PubMed] [Google Scholar] 114.Hu Q., Ren J., Li G., Wu J., Wu X., Wang G., Gu G., Ren H., Hong Z., Li J

It is also important to be aware of symptoms that may suggest either worsening B12 deficiency or poorly controlled blood glucose, and to seek prompt medical advice if you experience: Persistent fatigue, breathlessness, or pallor (possible anaemia) Tingling, numbness, or weakness in the hands or feet (possible B12-related neuropathy) Unsteadiness when walking, or changes in memory or thinking (possible signs of more severe B12 deficiency requiring prompt assessment) Increased thirst, frequent urination, or unexplained weight loss (possible hyperglycaemia) If you think you may be experiencing a side effect from a medicine for example, symptoms of B12 deficiency that you believe may be related to metformin you or your healthcare professional can report this via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk