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Our optimal CD47p/AZEpaclitaxome-2 can effectively encapsulate GEM at the optimal synergistic drug ratio in its interior and provide controlled and synchronized drug delivery to tumors, which boosts the antitumor efficacy by suppressing the CDA by enhancing oxidative stress, inhibiting microtubule formation, and increasing apoptosis, while minimizing the systemic side effects arising from the combination of GEM plus Taxol (Extended Data Fig

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Reflecting this new paradigm, the NIDDK has funded the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network (www.mappnetwork.org)

The molecular, cellular, pathologic, and physiologic targets will then be discussed with a particular emphasis on aspects relevant to child development