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The goal of the 3R Principle is to avoid animal experiments altogether (Replacement) and to limit the number of animals (Reduction) and their suffering (Refinement) in tests to an absolute minimum
Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats
TABLE 1 The potential of TCM targeting the gut microbiota-ferroptosis axis for treating PCOS
Older adults also face absorption issues like less intrinsic factor production and might need higher dosages
