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[13] showed that DNMT3a and DNMT3b did not induce de novo DNA methylation efficiently in mouse embryonic stem cells in the absence of DNMT1 gene

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(PubMed) Miret S, Tascioglu S, van der Burg M, Frenken L, Klaffke W

Similarly, 23 did not display any significant ROS formation, nevertheless, in the presence of HepG-2 cells, strong ROS formation was observed
