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In the ventrolateral preoptic area, morphine reduces the firing rate and hyperpolarizes sleep-promoting neurons (as assessed by sensitivity to norephinephrine treatment) but has no effect on non-sleep-promoting interneurons (Wang et al., 2013)

We'll also explore what research has revealed about this peptide bioregulator, while being clear about both the evidence and its limitations

Sleep, nutrition, stress, and lifestyle factors influence everything peptides are trying to support

In the dentate gyrus, granule cells are known to innverate hilar mossy cells, which in turn activate many mature dentate granule cells contralaterally (Figure 4B)
