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546,547 HIF-1 is a critical transcription factor that responds to changes in cellular oxygen levels
Previous reviews implicate a variety of hyperglycemia-dependent pathways, including the sorbitol, glucosamine and the AGE/RAGE pathways, possibly leading to oxidative stress and induction of inflammatory pathways [5]
Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, et al
10.1016/j.cmet.2013.08.019 41
