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LL6, the most promising novel small molecule kinase inhibitor obtained, induced apoptosis and suppressed the colony-forming capacities of various drug-resistant NSCLC cell lines, suppressed NSCLC cell migration, suppressed NSCLC xenograft tumor growth and Lewis lung carcinoma allograft tumor metastasis in mice, and markedly reduced the number and burden of lung tumors in KrasG12D/+ transgenic mice, with low toxicity (54)

doi: 10.1016/j.cld.2016.08.001

[DOI] [PubMed] [Google Scholar] 20.Choi D.Y., Ban J.O., Kim S.C

For instance, integrative metabolomics and metagenomics have revealed that gut bacteria (e.g., Prevotella copri) can synthesize BCAAs, thereby directly influencing host circulating levels and insulin sensitivity