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Iron is deposited in the brain cells of AD patients, and excessive iron will exacerbate oxidative damage and cognitive deficits ( Mechanisms of ferroptosis Iron homeostasis and ferroptosis The maintenance of iron homeostasis is essential for normal physiological function

Considerations: As with any copper-containing compound, there is a theoretical concern about copper toxicity with excessive systemic administration

Overexpression, one-step purification, and biochemical characterization of a recombinant -glutamyltranspeptidase from Bacillus licheniformis