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Adapted from Reference 10

In addition to its ability to treat heavy metal toxicity, dimercaprol has been approved by the FDA for the treatment of genetic disorders associated with copper homeostasis (Wilsons disease)

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase EMBO J 1997 16 : 64866494 Frantz B, Nordby EC, Bren G, Steffan N, Paya CV, Kincaid RL, Tocci MJ, O'Keefe SJ, O'Neill EA

Additionally, this review discusses critical challenges impeding the clinical translation of these therapies, including the standardization of GMP-compliant production processes, suboptimal homing efficiency of transplanted stem cells within the fibrotic pulmonary microenvironment, and inherent safety risks
