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In the most detailed conducted at The Ohio State University Eye and Ear Institute, sixty-one adults with chronic tinnitus were randomized to receive 3 mg melatonin or placebo nightly for 30 days followed by a 1-month washout period before switching over to the other treatment

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Pathophysiology Autosomal recessive mutations in the ATP7B gene (Wilson gene) on chromosome 13, which encodes for a membrane-bound, copper-transporting ATPase defective ATP7B protein [4] Reduced incorporation of copper into apoceruloplasmin