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The interconversion between Fe3+ and Fe2+ generates toxic ROS that are often detrimental to cells, and hence iron metabolism is strictly regulated within the body (24)

Ultimately, this results in constitutive activation of PI3K/Akt pathway, resulting in continued tumoral growth and resistance to EGFR blockade (149, 150)

The most common method is a Total Glutathione test, which measures the concentration of the antioxidant inside your red blood cells to assess your oxidative stress levels