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The amount of cytochrome c oxidase negative muscle fibers in treated mice decreased by 30%, the citrate synthase activity in muscle as a marker of mitochondrial biogenesis was doubled, liver lipid levels were restored and muscle mitochondrial ultrastructure was normalized (no ragged red fiber-like muscle fibers or mitochondria with distorted structure and cristae on electron microscopy)

Abbreviations UESL: Undifferentiated embryonal sarcoma of the liver CT: Computed tomography MRI: Magnetic resonance imaging PAS: Periodic acid-Schiff References Murawski M, Scheer M, Leuschner I, Stefanowicz J, Bonar J, Dembowska-Bagiska B, et al

The enzyme encoded by the PIP5K1A gene is localized to the plasma membrane, the Golgi complex, and in nucleus

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