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General Precautions: Vitamin B12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord

Topical application studies report minimal adverse effects

J Biol Chem (1978) 253(8):276976

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Dikalova A.E., Pandey A., Xiao L., Arslanbaeva L., Sidorova T., Lopez M.G., Billings F.T., Verdin E., Auwerx J., Harrison D.G., et al