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Neuron 24: 649658 [DOI] [PubMed] [Google Scholar] Lscher C, Nicoll RA, Malenka RC, Muller D 2000
Phan AT, Rashid A, Luthra R, Lopez-Alvarez E, Swisher S , Komaki R, Bresalier R, Ajani JA

While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician

Once you find the dose that is not creating these problems, over time your body may adjust to it and you won't have such a strong reaction
