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Mitochondrial function was severely compromised on multiple levels, including abnormalities in mitochondrial biogenesis (PGC1), nutrient sensors regulating fatty-acid entry into mitochondria (pAMPK/AMPK, SirT3, CPT1b), mitochondrial -oxidation of fatty-acids (HADHA, PPAR), electron transport chain complexes (I, II, III, V), ATP synthesis (ATP5A), and mitophagy (PINK1)

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However, our deepening understanding of the contribution of Fc-dependent effector functions to the protection mediated by vaccines and monoclonal antibodies warrants the development and validation of standardized assays to account for these functions and to assess their contribution to immunity and their possible use as correlates of protection (Box 2)

Consequently, tumors characterized by high TMB generally exhibit a more favorable response to immune checkpoint inhibitors