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Total symptom score decreased significantly compared to placebo across treatment groups of all doses 600-1800 mg/d oral ALA, yet there was a dose-dependent increase in nausea, vomiting, and vertigo, and therefore the lowest dose of oral ALA (600 mg/d) is recommended

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The cellularity of the TM declines linearly with a loss of 0.58% of cells per year and a 47% decline in absolute cell number over an 81-year study period [41]