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Description
Ficlatuzumab (AV-299) is a humanized, high-affinity monoclonal antibody that can block HGF/c-Met binding and mediate downstream phosphorylation of the signaling pathway (Tabernero et al., 2014)

To do this, it works on the hypothalamus to stop the growth hormone-releasing hormone and also on the pituitary to stop the growth hormone release

[PMC free article: PMC3113287] [PubMed: 20472501] 237

The two compounds work through entirely separate biological pathways
