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Distribution and function of the hydrogen sulfidesensitive TRPA1 ion channel in rat urinary bladder

According to the phase 1 clinical data disclosed by Alnylam, 9 givosiran dosed at 2.5 mg/kg once-monthly significantly reduced the levels of ALAS1 mRNA, delta aminolevulinic acid (ALA) and porphobilinogen (PBG), with higher than 80% inhibition efficiency, which was accomplished with a 79% decrease in the mean annualized attack rate compared to that of the placebo

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To determine whether this effect is attributed to direct modulation of lipid peroxidation, the authors employed the fluorescence-enabled inhibited autoxidation (FENIX) assay, which quantifies liposomal membrane peroxidation