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The phase 1 clinical trials evaluated escalating doses of CB-839 in patients with advanced solid tumors among the patients with triple-negative breast cancer, RCC, mesothelioma, NSCLC, fumarate hydratase (FH)-deficient tumors, succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GIST) or non-GIST tumors, cMyc-mutated tumors, and isocitrate dehydrogenase-1 (IDH1)- or IDH2-mutant tumors in combination with standard of care chemotherapy

Drug Design Reviews-Online (Discontinued) (2005) 2:1217

26,382,383 Intravenous injection of LDHA/B inhibitor NCI-006 inhibits LDH activity and its growth in pancreatic cancer mouse models, so as oral administration of LDHA inhibitor GNE-140

Dietary sources rich in Mg include nuts, seeds, whole grains, and leafy green vegetables, and supplementation is also available