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In neurons, Grx has a protective effect on redox-sensitive enzymes and ion channels, meaning that its dysfunction is implicated in several neurodegenerative disorders involving protein misfolding and redox signaling dysregulation (Ogata et al., 2021)

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ER deficiency exacerbates colitis and enhances ferroptosis, while its activation upregulates GPX4 level, thereby mitigating ferroptosis and reducing inflammation [96]

However, in another study, CBD given chronically decreased oxidative stress markers in rats with hypertension, but exhibited prooxidative effects in normotensive control animals, especially in WistarKyoto rats (Table 2) [96]