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Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells
Following nickel purification (Figure 4A, lanes 2 and 3), the enriched fraction showed a high degree of purity and appropriate size as a monomer in absence of glutathione (lane 2) or as a dimer in the presence of glutathione (lane 3)
However, rapidly absorbing drugs can saturate the gut UGT at high concentrations, so that they bypass intestinal metabolism and are predominantly glucuronidated in the liver
