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However, selenium should not be routinely supplemented in non-deficient individuals [55, 63], in particular because chronic excess may lead to toxicity (selenosis)
But, some people should be careful with B12 supplements

Furthermore, naringenin, a promising bioactive compound, is postulated to modulate cellular adaptive responses to hypoxic conditions through its influence on HIF-1, TNF, and NF-B signaling cascades, along with estrogen-mimetic activities
