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Itoh et al., 2000
106 HIF signaling pathway Hypoxia-inducible factors (HIFs), consisting of an oxygen-sensitive subunit and a constitutively expressed HIF-1 subunit, are major regulators of adaptive responses to hypoxia and directly activate the expression of multiple target genes to maintain cellular oxygen homeostasis
Notably, the production of cultivated, edible mushrooms worldwide has increased more than 30-fold since 1978, whereas the population has only increased by about 17-fold during the same period (10,317)
