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Without this active form of B12, homocysteine cannot fully recycle back to Methionine nor go down the transsulfuration pathway to become glutathione

[DOI] [PubMed] [Google Scholar] 43.Testa B, Testa D, Mesolella M, DErrico G, Tricarico D, Motta G

For instance, the use of erastin can reduce the efflux of the multidrug resistance protein ATP-binding cassette subfamily B member 1 (ABCB1), leading to increased accumulation of chemotherapeutic drugs within tumor cells, thereby reversing resistance to docetaxel and platinum-based drugs (Zhou et al., 2019)

Sodium-glucose cotransporter-2 inhibition normalizes metabolic derangements in the ischemic myocardium