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doi:10.1038/sj.bmt.1702196 68Regional Medicines Optimisation Committee (RMOC) Advisory Statement: Sequential Use of Biologic Medicines

The hypothesis that the vitamins B1, B6, and B12 act in biochemical synergy in the nervous system by supplying energy, enabling signal transduction, and providing neuroprotection in the form of the myelin sheath is supported by numerous in vitro and animal studies [12]

Also, some intestinal irregularities can hinder uptake as well

Many people notice an energy lift within hours, but its best to monitor how you feel and communicate with your provider if you have any concerns
