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It induces its own metabolism, which complicates dosage titration

In the spinal cord, the central gray matter is supplied by branches of the ventral spinal artery that enter the ventral sulcus, and lesions of these branches affect the gray matter of the cord rather selectively

doi: 10.1084/jem.20190314 26 HuangYXuWZhouR

One animal study found that mice given PQQ had significantly less inflammatory damage to brain tissue, compared with the control group ( In another study in obese mice treated with PQQ during pregnancy and lactation, their offspring exhibited significantly fewer inflammatory markers in liver tissue and were less likely to express inflammatory genes than the offspring of mice that didnt get PQQ ( One small, 3-day study in 10 people evaluated the effects of taking a daily PQQ supplement on common markers of inflammation, such as C-reactive protein (CRP), interleukin-6 (IL-6), and blood sugar and cholesterol levels ( CRP and IL-6 levels dropped significantly, but no meaningful changes in cholesterol or blood sugar occurred ( Although these results are promising, the data isnt strong enough to suggest that PPQ treats or prevents inflammatory conditions