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Glutathione S-transferase pi (GST-pi) is up-regulated by oxidative stress through NF-B 53
Overall, the literature suggests that aging is associated with increased OS in brain and body, but the timing and regional distribution of changes requires further study
[DOI] [PubMed] [Google Scholar] 55.Al-Jenoobi F
The Roadmap for a rare disease should identify experiments necessary to understand the disease, identify drug repurposing opportunities, and explore the use of emerging technologies like gene therapy, ASOs, CRISPR/Cas9 and others to treat this disease
