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Thus, it is recommended to use fermented pollen which is more acceptable for nutrient absorption by the digestive tract of humans (194, 195) because microbes degrade the external pollen walls during fermentation, and its internal nutrients can easily be consumed (8)

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But thats mainly an assumption at this time, as there isnt very much research on TB-500 itself

Rapid endothelial restoration and activation of the major collaterals (in addition, there are abundant anastomoses between individual vessels on both surfaces of the large intestine (Kachlik, et al., 2010)) may reorganize blood flow (Vukojevic et al., 2018