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Intracellular methionine level of CD19 + B cells is largest increased after CpG/IFN-/BCR crosslinking simulation, and methionine commits the differentiation of CD19 + B cells through driving the histone modification H3K27me3 of BACH2 (a vital transcriptional factor for B-cell differentiation), and this process refers to activation of spleen tyrosine kinase (Syk) or mTORC1 signaling and up-regulation of expression of methyltransferase enhancer zeste homolog 2 (EZH2) (105)

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MOTS-c half-life is approximately 2 to 4 hours, but the downstream cellular effects (mitochondrial biogenesis, gene expression changes) persist well beyond serum clearance

Violaceimides AE, sulfur-containing metabolites from a sponge-associated fungus Aspergillus violaceus