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Het peptide upreguleerde genen betrokken bij: Collageensynthese verhoogde expressie van COL1A1, COL1A2, COL2A1, COL3A1 en COL5A1 Extracellulaire matrix decorine, lumicaan, fibronectine en proteoglycanen Wondgenezing metalloprotenase-remmers (TIMP1, TIMP2) die weefselafbraak tegengaan Anti-oxidatieve verdediging superoxide dismutase (SOD), glutathione peroxidase Angiogenese vasculaire endotheliale groeifactor (VEGF) productie Tegelijkertijd downreguleerde GHK-Cu genen geassocieerd met ontstekingen, waaronder pro-inflammatoire cytokines en matrix metalloprotenasen (MMP-1, MMP-2, MMP-9) die verantwoordelijk zijn voor de afbraak van collageen en elastine in de huid

Keywords: antioxidants, oxidative stress, sepsis, infection, cysteine Oxidative damage and antioxidant defense, inflammation, and immunity Reactive oxygen species and oxidative stress While the oxidative deterioration of lipids has been known for a long time, it was only in the late 1960s that we became aware of the importance of these chemical processes in pathology and toxicology with the finding that lipid peroxidation or rancidification occurred also in biological systems

Venturini, 1973), are critical for oxidative phosphorylation and energy production