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GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 auto-reactive CD4 T cells

Cohens d was 0.07 for IM vs SL routes, 0.06 for oral vs IM routes, and 0.22 for oral vs SL routes

Patients typically feel the increased energy, mental clarity, and mood enhancement from each B12 injection for 5-15 days on average before it tapers off

Addressing even one of these areas can create meaningful improvement across multiple systems