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prescription meds and some OTC meds (Tylenol) UV radiation, medical X-rays, chemotherapy, electromagnetic fields Alcohol use and abuse Unrelieved stress, poor sleep, and lack of exercise or too strenuous exercise which can produce too many free radicals Poor diet, especially one thats low in vitamins, minerals or antioxidants The natural aging process, which drops cellular glutathione production on average 10% per decade In short, when your body's demand for glutathione outpaces its supply, oxidative stress ramps up and that's when problems start

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FIGURE 2 3.1 Subcellular dysfunction and oxidative stress 3.1.1 Mitochondria and oxidative stress Mitochondrial dysfunction plays a critical role in the pathogenesis of BIPN

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Organic Seed Alliance, Port Townsend, WA, pp 5051 [Google Scholar] Nukumizu Y, Wada T, Tominaga-Wada R (2013) Tomato ( Solanum lycopersicum ) homologs of TRIPTYCHON (SlTRY) and GLABRA3 (SlGL3) are involved in anthocyanin accumulation

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