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As discussed before, AD is a multifactorial condition and therefore numerous factors (both hereditary and lifestyle) apart from A accumulation itself can contribute to or pose a risk to the development of this neurodegenerative disease [85, 86]

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Subsequently, some other bacteria such as Bacillus thuringiensis , Bacillus cereus , Bacillus licheniformis , Lactobacillus delbrueckiistrain, Lactococcus lactisstrain and Corynebacterium variabile were also identified to have -PL synthetases in their genomes, indicating that bacteria also have the potential to be industrial -PL producers (Shukla and Mishra, 2013

Killilea and Ames [32] have shown that primary fibroblasts grown in vitro in magnesium deficient medium have accelerated shortening of telomeres and enhanced expression of senescence related biomarkers in addition to loss of their replicative potential