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While initial attempts have achieved partial recapitulation of testicular cell interactions, these models have not yet demonstrated the capacity to support complete spermatogenesis from stem cells to mature sperm ( In the interim, more established in vitro approaches offer valuable alternatives for mechanistic studies
Ca 2+ and cAMP can facilitate NLRP3 activation via the calcium-sensing receptor (CaSR) [92]
doi: 10.1177/0271678X20984565
