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In addition, although mtDNA-mediated CR mutations increase with aging in control healthy brains, the elevation is higher in the brains of AD, Down syndrome (DS), and DS with Alzheimer (DSAD) patients (436)

Common additions include: B1 (Thiamine): Supports carbohydrate metabolism and energy production B2 (Riboflavin): Required for fat and protein metabolism B3 (Niacinamide): Supports over 400 enzyme reactions, including those involved in energy metabolism B5 (Dexpanthenol): Essential for the synthesis of coenzyme A, which is required for fatty acid metabolism B6 (Pyridoxine): Supports amino acid metabolism and neurotransmitter synthesis B12 (Methylcobalamin/Cyanocobalamin): Critical for energy production, red blood cell formation, and methylation reactions Why they matter: B vitamins are cofactors in virtually every metabolic process

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Williams M, Jones SC, Caputi P, Iverson D