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Carnitine and functional hypothalamic amenorrhea Functional hypothalamic amenorrhea (FHA) is a form of hypogonadotropic hypogonadism that results from an aberration in the pulsatile release of hypothalamic gonadotropin-releasing hormone (GnRH), which causes decreased gonadotropin release leading to reduced estradiol production in the ovary [41]

Interestingly, patients who received 100 mg CoQ 10 + 500 mg vit E + -blockers, compared to those only treated with -blockers, showed a beneficial effect on inner retinal function, electroretinogram improvement and enhancement of the visual cortical responses (measured by visual-evoked potential enhancement) [91]

The number of included studies was limited, most being small-sample and short-term clinical trials, and the lack of large-scale, robust RCTs restricts the strength of the conclusions