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Moreover, maintenance of mitochondrial GSH homeostasis may be a limiting factor for the survival of metastatic cells in the immediate period following intra-sinusoidal arrest and interaction with activated vascular endothelial cells
It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)
As a result: Preclinical strategies are exploring selective reduction of glutathione in tumor cells to increase chemosensitivity