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When any of the key ETC genes are deficient or ETC action is inhibited, the number of ROS increase, and high levels of accumulated ROS may induce ferroptosis

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Glycolysis generates ATP but also provides metabolic intermediates that enter many other metabolic pathways (6)

For reproductive applications, this strategy is often well suited to mechanistic stratification because it yields stable axes that can be interpreted in terms of coherent programs, including progesterone-response attenuation, decidualisation trajectory deficits, inflammatory activation, or metabolic stress, while supporting subsequent assay compression into targeted panels [450]