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This may be one of the mechanisms by which cannabis abuse triggers depression

Miele, L

Supplementing beef heifer during the first 63d of gestation with one-carbon cycle components (dietary RPM, rumen-protected choline, and injection of vitamin B 12 and folic acid) increased the availability of vitamin B 12 , folate and folate intermediates in maternal serum and promoted greater levels of 5-CH 3 -THF in the allantoic and amniotic fluid (Syring et al., 2024)

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