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10.1016/j.regpep.2009.05.008 3 BarisicI.BalenovicD.KlicekR.RadicB.NikitovicB.DrmicD.et al (2013)

Mild side effects and potential risks, which should be referred to a doctor if they persist or worsen, include: pain, redness, or itching at the site of the injection mild diarrhea swelling sensation in the body More serious side effects, which require immediate medical attention, include: muscle cramps irregular heartbeat unusual weakness or tiredness swelling of the ankles or feet Severe reactions are very rare but require emergency intervention

Human studies provide topical and wound-care context [1] [2] [3] [4] [5] , while an animal wound model provides local-administration context [6]

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