hepatic glutathione reductase peroxidase and glutathione activities in 𧬠Hepatic Glutathione Synthesis: The
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In the proteinprotein interaction (PPI) network, we obtained that Nrf2 regulates ferroptosis primarily by directly affecting the synthesis and function of GPX4 and the peroxisome proliferator-activated receptor gamma (PPAR) pathway, and we hypothesize that the regulation of intracellular iron concentration by Nrf2 is mainly through the Nrf2HO-1 axis

[DOI] [PubMed] [Google Scholar] Baumgartner T, Zurauskait G, Wirz Y, Meier M, Steuer C, Bernasconi L, Huber A, Christ-Crain M, Henzen C, Hoess C, Thomann R, Zimmerli W, Mueller B, Schuetz P