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59 , 61 PK deficiency is due to a mutation in the PKLR gene that codes for PK in red blood cells and hepatocytes
9-.beta.-d-ribofuranosyladenine 37
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We used mice from a somatic transgenic model of MYCdriven liver tumorigenesis 28, which also have elevated MYC and depleted GCLC protein expression (Fig EV3A)
