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By blocking NNMT, 5-Amino-1MQ drives several metabolic benefits: Boosts NAD Levels Inhibiting NNMT preserves more nicotinamide for NAD synthesis, leading to enhanced mitochondrial function, increased cellular energy output, and activation of sirtuins , the proteins involved in longevity and DNA repair

Adding semaglutide to retatrutide would duplicate GLP-1 receptor activation, which could increase side effects without proportionally increasing efficacy