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If -syn is involved in neuronal activity, could its sequestration into pathologic aggregates have implications on synaptic transmission

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The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms

Probiotic strains such Lactobacillus reuteri , Lactobacillus plantarum , and Bifidobacterium longum have showed potential in lowering TMAO levels by suppressing TMA-producing bacteria and increasing beneficial microbial populations